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Animal Health Research Centre (CISA)

The Animal Health Research Centre, located in Valdeolmos, Madrid, is dedicated to research and surveillance activities for the prevention, diagnosis and control of animal transmissible diseases.

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NOEMÍ SEVILLA HIDALGO

DIRECTORA

Ubicación

Valdeolmos- Alalpardo, Madrid, Carretera de Algete a El Casar, Km 8

91 620 2300

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It is particularly focused on emerging, re-emerging and transboundary infectious diseases of livestock causing economical and sanitary impact, including zoonosis that may cause restrictions in the international trade and a serious effect on public health and food security. Its primary mission is to promote advanced research, technology development, cooperation with national and international bodies, and technology transfer in the area of animal health, following the strategic priorities agreed by national and international forums and organizations of relevance in the area.

The CISA Biosafety facility belongs to the Network of High Biosafety Laboratories (RLASB) in the map of Singular Scientific Technical Facilities (ICTS) of the Ministry of Science, It takes part of the Laboratory Network for Biological alert (RELAB), under the Presidency of the Government to deal with threats caused by biological agents.

INIA-CISA is Reference Laboratory for the European Union and for the Food and Agriculture Organization of the United Nations (FAO) for African Swine Fever (ASF). This nomination requires of great capacity to respond to emergencies and outbreaks associated to this disease. As such these laboratories develop an intense activity in diagnostic matters, provision of standards and controls, and harmonization of National Reference Laboratories. An active regular collaboration is established with more than fifty countries worldwide.

INIA-CISA is in charge of Reference Centre in Biosafety for FAO (INIA-CISA) carrying out advising on biosafety matters and bio-contention facilities. It is the solely biosafety facility in Spain authorized to carry out “in vivo” experiments with animal with Foot and Mouth disease virus.

Important collaboration is maintained with a number of national and international Institutes, highlighting the relationship with the Ministry of Agriculture of Spain, supporting scientific-technical activities in the needs of the National Reference laboratories

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Research

The 10,824 m2 High Biological Safety facility includes 40 NCB3 biological containment level laboratories, 2 NCB4 (OIE) laboratories and 1 animal facility in the NCB3 area consisting of 15 containment boxes for large and small animals, and 4 NCB4 boxes (OIE ) adapted for in vivo work with zoonoses such as Flavivirus, Bunyavirus, coronavirus, and viruses that are transmitted through the air such as Foot-and-Mouth Disease.

Inside, all surfaces are covered with special resins, which provide insulation and protection. All conduits through walls, floors, and ceilings are independently sealed. Communication with the outside is done through air-locks double door decontamination systems, barrier autoclaves and surface decontamination barrier systems.

The INIA-CISA is organized into six research groups. Through research projects and collaboration contracts and its international reference laboratories, it maintains an intense collaboration with Institutions from more than 60 countries on all continents. At the national level, maintaining relations with the Ministry of Agriculture, Fisheries and Food, CSIC Centers and Universities stand out.

The research groups maintain collaborations with companies in the animal sector aimed mainly at the evaluation of biologicals, efficacy studies of vaccines and disinfectants, and development and validation of diagnostic kits, production of antigens for commercial kits, etc.

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INIA-CISA is organized into six research groups, as it is shown below, which are involved in three main areas: i) epidemiology, modelling and surveillance, ii) Immunology and virology: new developments in diagnosis and vaccines iii) pathology and transmission of emerging and re-emerging animal diseases.

Epidemiology and environmental health: Spatio-temporal epidemiology of transboundary and emerging animal infectious diseases. Diagnosis and epidemiology of priority diseases of zoonotic and/or economic interest for the livestock and/or environmental sector. Environmental monitoring of antimicrobial resistance.
Emerging and Transboundary Diseases: They work on different aspects of priority, notifiable animal viral diseases that pose a serious threat to livestock. They study their transmission and contagion mechanisms, reservoirs, diagnosis or evolution of circulating viruses, of diseases such as African swine fever (ASF), Classical swine fever (CSF), Swine vesicular disease (SVD), Peste des petits ruminants (PPR), and zoonoses such as West Nile virus fever / encephalitis (WN), Avian influenza and Covid19. They work especially in the development of new technologies for prevention, diagnosis and control.
They provide specialized support to the National Reference Laboratories of the EU countries as an EU Reference Laboratory and at a global level through the Reference Center of the Food and Agriculture Organization of the United Nations (FAO). They work closely with the Ministry of Agriculture, Fisheries and Food on complex sanitary studies and support to its Central Veterinary Reference Laboratory.
New Strategies For The Control of relevant pathogens in animal health: Development of new control strategies of different pathogens in Animal Health, to analyze the immune response to the pathogens in natural hosts, to identify and characterize new vaccine development and by the development of tools for the specific and differential diagnosis for animal pathogens such us Foot-and-mouth disease virus (FMDV), , Peste de petites ruminants (PPRV), Bluetongue virus (BTV), new variant rabbit hemorrhagic disease virus (RHDV2), SARS-Cov2 among other zoonosis.
Fish Pathology and Inmunology: The main objective of our group is to understand the regulation mechanisms of the immune response in fish, especially those triggered in response to viral or parasitic infections. Our research pretends to use this increased knowledge of the resistance mechanisms in fish to design more effective antiviral vaccines, as well as novel molecular adjuvants.
Cellular and molecular biology of prions: The general objective of the group is to advance in the knowledge of the Transmissible Spongiform Encephalopathies (TSEs) and the agent causing these diseases. Three lines of work are being developed: i) development of bioassay of high sensitivity for prion detection and diagnosis; ii) study of the elements involved in prion replication and pathogenesis and iii) study of the different prion strains in the different species and its capability of transmission to human.
Immunoprofilaxis of vector-borne viral diseases: This group aims to develop immunization strategies against arboviruses of interest in Animal Health as well as to establish animal infection models and virus detection tools. Thier work is focused mainly on Rift Valley fever virus (RVFV) and bluetongue virus (BTV). Other viruses of interest are Crimean-Congo haemorrhagic virus (CCHFV) and African Horse sickness virus (AHSV) and SARS-Cov2 among other zoonosis.

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Research Groups

Epidemiology and Environmental Health
Emerging and Transboundary Diseases
New Strategies for the Control of relevant Pathogens in Animal Health
Fish Immunology and Pathology
Molecular and Cellular Biology of Prions
Immunoprofilaxis of Vector-Borne Viral Diseases

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Instalations

Laboratorio de Alta Seguridad Biológica NCB3 y NCB3+

El Laboratorio de Alta Seguridad Biológica del INIA-CISA cuenta con una superficie total de 10.824 m2 en la que se encuentran ubicados 40 laboratorios de NCB3 (OMS) y 2 laboratorios de NCB4 (OIE).

Animalario de Alta Seguridad Biológica NCB3 y NCB3+

El Animalario de Alta Seguridad Biológica del INIA-CISA cuenta con 15 boxes experimentales independientes en la zona NCB3 (OMS) de contención para grandes y pequeños animales y 4 boxes NCB4 (OIE) adaptados para trabajos in vivo con enfermedades de importancia en sanidad animal, zoonosis y Fiebre Aftosa.

Zona Exterior NCB2

En la zona exterior de nivel NCB2, se localizan 10 laboratorios convencionales equipados con infraestructura y equipos apropiados para estudios epidemiológicos y modelización, secuenciación, estudios de epidemiología y biología de patógenos y vida silvestre.

Garcia-Sanchez P.; Romero-Trancón D.; Sainz T.; Calvo C.; Iglesias I.; Perez-Hernando B.; Hurtado-Gallego J.; Sánchez R.; Alcolea S.; Moya L.; Mendez-Echevarria A; (2024)
The role of veterinarians in zoonosis prevention: Advising families of immunocompromised children with pets
One Health
DOI: 10.1016/j.onehlt.2023.100662
Costa-Silva S, Sacristán C, Soares RM, Carvalho VL, Castilho PV, Cremer M, Ewbank AC, Duarte-Benvenutto A, Faita T, Navas-Suárez P, Ramos MK, Nigro PN, Alves FC, Pereira LG, Vieira JV, Lemos GG, Peres NS, Silvestre-Perez N, Catão-Dias JL, Keid LB. (2023)
Short-finned pilot whale strandings associated with Pilot whale morbillivirus, Brazil
Emerging Infectious Diseases
DOI: 10.3201/eid2901.221549
Garcia-Sanchez, P., Iglesias I., Falces-Romero I., Serrano-Villar M., Calvo C., Sainz*T., Mendez-Echevarría A (2023)
BALANCING THE RISKS AND BENEFITS OF PET OWNERSHIP IN PEDIATRIC TRANSPLANT RECIPIENTS
Transplantation
DOI: 10.1097/TP.0000000000004419
P. Garcia-Sanchez, E. Aguilar-Valero, T. Sainz, C. Calvo, I. Iglesias, D. Bueno, E. Frauca, E. Ramos-Boluda, A. Alcolea-Sanchez, L. García-Guereta, A. Alonso-Melgar, F. Esperón, A. Mendez-Echevarria (2023)
Immunocompromised Children and Young Patients Living with Pets: Gaps in Knowledge to Avoid Zoonosis
Transboundary and Emerging Diseases
DOI: 10.1155/2023/2151761
Marín-Moreno A.; Canoyra S.; Fernández-Borges N.; Espinosa J.C.; Torres J.M; (2023)
Transgenic Mouse Models for the Study of Neurodegenerative Diseases
Frontiers in Bioscience - Landmark | 28
DOI: 10.31083/j.fbl2801021
Martínez Avilés M.; Bosch J.; Ivorra B.; Ramos Á.M.; Ito S.; Barasona J.Á.; Sánchez-Vizcaíno J.M; (2023)
Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations
Research in Veterinary Science
DOI: 10.1016/j.rvsc.2023.104964
Lorenzo M.M.; Marín-López A.; Chiem K.; Jimenez-Cabello L.; Ullah I.; Utrilla-Trigo S.; Calvo-Pinilla E.; Lorenzo G.; Moreno S.; Ye C.; Park J.-G.; Matía A.; Brun A.; Sánchez-Puig J.M.; Nogales A.; Mothes W.; Uchil P.D.; Kumar P.; Ortego J.; Fikrig E.; Martinez-Sobrido L.; Blasco R; (2023)
Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models
Vaccines | 11
DOI: 10.3390/vaccines11051006
López J.; Mogedas M.; Ballesteros C.; Martín-Maldonado B.; Sacristán I.; García R.; Ortiz J.C.; Esperón F; (2023)
Infectious agents present in monk parakeet (Myiopsitta monachus) and rose-ringed parakeet (Psittacula krameri) invasive species in the parks of Madrid and Seville;Spain
Frontiers in Veterinary Science
DOI: 10.3389/fvets.2023.1162402
de Francisco O.N.; Sacristán I.; Ewbank A.C.; Velarde R.; Afonso I.; Garcia-Ferré D.; Martín-Maldonado B.; Esperón F.; Iglesias I.; de la Torre A.; Margalida A.; Sacristán C; (2023)
First detection of herpesvirus and hemosporidians in the endangered Pyrenean Capercaillie (Tetrao urogallus aquitanicus)
Scientific Reports
DOI: 10.1038/s41598-023-48123-3
Napolitano C.; Sacristán I.; Acuña F.; Aguilar E.; García S.; López-Jara M.J.; Cabello J.; Hidalgo-Hermoso E.; Poulin E.; Grueber C.E; (2023)
Assessing micro-macroparasite selective pressures and anthropogenic disturbance as drivers of immune gene diversity in a Neotropical wild cat
Science of the Total Environment
DOI: 10.1016/j.scitotenv.2023.166289
Rodríguez A.; Sacristán C.; Iglesias I.; de la Torre A; (2023)
Salmonella assessment along the Spanish food chain: Likelihood of Salmonella occurrence in poultry and pig products is maintained across the food chain stages
Zoonoses and Public Health
DOI: 10.1111/zph.13076
Muñoz-Pérez C.; Martínez-López B.; Gómez-Vázquez J.P.; Aguilar-Vega C.; Bosch J.; Ito S.; Martínez-Avilés M.; Sánchez-Vizcaíno J.M; (2023)
Quantitative risk assessment of African swine fever introduction into Spain by legal import of swine products
Research in Veterinary Science
DOI: 10.1016/j.rvsc.2023.104990
Martínez-Avilés M; (2023)
African Swine Fever: Epidemiology;the Design of New Diagnostic Methods;and Vaccine Development
Pathogens
DOI: 10.3390/pathogens12081042
Morelle K.; Barasona J.A.; Bosch J.; Heine G.; Daim A.; Arnold J.; Bauch T.; Kosowska A.; Cadenas-Fernández E.; Aviles M.M.; Zuñiga D.; Wikelski M.; Vizcaino-Sanchez J.M.; Safi K; (2023)
Accelerometer-based detection of African swine fever infection in wild boar
Proceedings of the Royal Society B: Biological Sciences
DOI: 10.1098/rspb.2023.1396
Aguilar-Vega C.; Muñoz-Pérez C.; Sánchez-Vizcaíno J.M.; Martínez-Avilés M.; Bosch J; (2023)
Eco-Sanitary Regionalization of Wild Boar (Sus scrofa) in the Western Palearctic Realm as a Tool for the Stewardship of African Swine Fever
Transboundary and Emerging Diseases
DOI: 10.1155/2023/8080496
Encinas P.; Escalera A.; Aydillo T.; Iglesias I.; Nelson M.I.; García-Sastre A.; del Real G; (2023)
SARS-CoV-2 Neutralizing Antibodies in Free-Ranging Fallow Deer (Dama dama) and Red Deer (Cervus elaphus) in Suburban and Rural Areas in Spain
Transboundary and Emerging Diseases
DOI: 10.1155/2023/3324790
Ito S.; Bosch J.; Aguilar-Vega C.; Isoda N.; Martínez-Avilés M.; Sánchez-Vizcaíno J.M; (2023)
Development of an Effective Oral Vaccine Dissemination Strategy against Classical Swine Fever for Wild Boar in Gifu Prefecture;Japan
Transboundary and Emerging Diseases
DOI: 10.1155/2023/9484441
Pérez-Ramírez, E.; Iglesias, I.; Alvar, J.; Casas, I. (2023)
¿Podría la gripe aviar A(H5N1) causar una nueva pandemia?
Anales RANM
DOI: 10.32440/ar.2023.140.02.rev08
Ewbank, A.C.; Duarte-Benvenuto, A.; Zamana Ramblas, R.; Gattamorta, M.A.; Neri Godoy, S.;Gravinatti, M.L.;Brandão, P.E.;Catão-Dias, J.L.;Sacristán, C. (2023)
Herpesvirus, Flavivirus, and Coronavirus Surveillance in Magnificent Frigatebirds (Fregata magnificens), Alcatrazes Archipelago, Southeastern Brazil
J. of Wildlife Diseases | 59 : 353-358
DOI: 10.7589/JWD-D-22-00146
Sacristán C; Ewbank A.C; Sánchez-Sarmiento A.M; Duarte-Benvenuto A; Borges J.C.G; Rebelo V.A; Díaz-Delgado J; Borges Keid L; Catão-Dias J.L; (2022)
Erysipelas in a stranded common bottlenose dolphin: first report in a South American odontocete
Brazilian Journal of Microbiology
DOI: 10.1007/s42770-022-00810-5
García R.M; Martínez-Fernández J; Rodríguez A; de la Torre A; (2022)
Identification of sentinel plant species for evaluating phytotoxicity of veterinary antibiotics in Mediterranean Europe
Environmental Sciences Europe
DOI: 10.1186/s12302-022-00608-0
Otero A; Barrio T; Eraña H; Charco J.M; Betancor M; Díaz-Domínguez C.M; Marín B; Andréoletti O; Torres J.M; Kong Q; Badiola J.J; Bolea R; Castilla J; (2022)
Glycans are not necessary to maintain the pathobiological features of bovine spongiform encephalopathy
PLoS Pathogens
DOI: 10.1371/journal.ppat.1010900
Schmitz M; Canaslan S; Espinosa J.C; Fernández-Borges N; Villar-Piqué A; Llorens F; Varges D; Maass F; Torres J.M; Hermann P; Zerr I; (2022)
Validation of Plasma and CSF Neurofilament Light Chain as an Early Marker for Sporadic Creutzfeldt-Jakob Disease
Molecular Neurobiology
DOI: 10.1007/s12035-022-02891-7
Bueno I; Rodríguez A; Beaudoin A; Arnold W.A; Wammer K.H; de la Torre A; Singer R.S; (2022)
Identifying the spatiotemporal vulnerability of soils to antimicrobial contamination through land application of animal manure in Minnesota;United States
Science of the Total Environment
DOI: 10.1016/j.scitotenv.2022.155050
Nicolás Francisco O; Afonso Jordana I; Garcia Ferré D; Roig Simón J; Ewbank A.C; Margalida A; Sacristán I; Foulché K; Ménoni E; Sacristán C; (2022)
Sedation of Wild Pyrenean Capercaillie (Tetrao urogallus aquitanicus) Using Intramuscular Midazolam
Animals
DOI: 10.3390/ani12141773
Hidalgo-Hermoso E; Ruiz-Fons F; Cabello-Stom J; Ramírez N; López R; Sánchez F; Mansell M; Sánchez C; Simonetti J.A; Peñaranda D; Stipicic G; Moreira-Arce D; Cariñanos A; Barría I; Silva A; Millán J; Esperón F; (2022)
Lack of Exposure to Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis in Chilean Cervids;and Evidence of a New Mycobacterium-like Sequence
Journal of Wildlife Diseases
DOI: 10.7589/JWD-D-21-00135
Nieto-Claudin A; Esperón F; Apakupakul K; Peña I; Deem S.L; (2022)
Health assessments uncover novel viral sequences in five species of Galapagos tortoises
Transboundary and Emerging Diseases
DOI: 10.1111/tbed.14391
Moraleda C; Domínguez-Rodríguez S; Mesa J.M; García-Sánchez P; De La Serna M; Alonso-Cadenas J.A; Bermejo A; Sabrido G; Martínez-Campos L; González-Posada A.F; Illán-Ramos M; Cobos-Carrascosa E; Ballesteros Á; Galán J.C; Llorente F; Aguilera-Alonso D; Jiménez A.B; Catalán P; Dahdouh E; Navarro I; Fernández-Garoz B; Mendoza P; Pérez-Jorge C; Cabezas-Fernández T; Blázquez-Gamero D; Rivas G; Gonzalez-Donapetry P; Sáez E; Fernández-Pinero J; Lucas-Fernández J; Pérez-Ramírez E; Merino P; Miragaya S; Lorente J; Iglesias I; Tagarro A; the EPICO working group (2022)
Oral saliva swab reverse transcription PCR for Covid-19 in the paediatric population
Archives of Disease in Childhood | 107 : 1051-1058
DOI: 10.1136/archdischild-2021-323712
Lial H.C; Navas-Suárez P.E; Ewbank A.C; Exposto Novoselecki H; Ferreira-Machado E; dos Santos Cirqueira C; de Azevedo Fernandes N.C.C; Esperón F; Catão-Dias J.L; Sacristán C; (2022)
Adenovirus surveillance in wild carnivores from Brazil
Infection;Genetics and Evolution
DOI: 10.1016/j.meegid.2022.105246
Lopes F; Esperón F; Bravo-Barriga D; Frontera E; Cabrero-Sañudo F.J; Gil-Tapetado D; Orejas P; Alonso R; (2022)
Identification of the intermediate host of Gongylonema sp; the etiological agent of the necrotic oropharyngeal disease of the Scops owl (Otus scops)
Parasitology International
DOI: 10.1016/j.parint.2021.102443
Chiem K; Nogales A; Martinez-Sobrido L; (2022)
Generation;Characterization;and Applications of Influenza A Reporter Viruses
Methods in Molecular Biology
DOI: 10.1007/978-1-0716-2453-1_19
Nogales A; Chiem K; Breen M; DeDiego M.L; Parrish C.R; Martínez-Sobrido L; (2022)
Generation and Characterization of Single-Cycle Infectious Canine Influenza A Virus (sciCIV) and Its Use as Vaccine Platform
Methods in Molecular Biology
DOI: 10.1007/978-1-0716-2168-4_13
Brun A; (2022)
An Overview of Veterinary Viral Diseases and Vaccine Technologies
Methods in Molecular Biology
DOI: 10.1007/978-1-0716-2168-4_1
Marín-López A; Utrilla-Trigo S; Jiménez-Cabello L; Ortego J; (2022)
Recombinant Modified Vaccinia Virus Ankara Development to Express VP2;NS1;and VP7 Proteins of Bluetongue Virus
Methods in Molecular Biology
DOI: 10.1007/978-1-0716-2168-4_10
Moreno S; Borrego B; Brun A; (2022)
Using RVFV as a Vector Platform for the Expression of Ruminant Disease Antigens
Methods in Molecular Biology
DOI: 10.1007/978-1-0716-2168-4_12
Hidalgo-Hermoso E; Cabello J; Novoa-Lozano I; Celis S; Ortiz C; Kemec I; Lagos R; Verasay J; Mansell-Venegas M; Moreira-Arce D; Vergara P.M; Millán J; Esperón F; (2022)
MOLECULAR DETECTION AND CHARACTERIZATION OF HEMOPLASMAS IN THE PUDU (PUDU PUDA);A NATIVE CERVID FROM CHILE
Journal of Wildlife Diseases
DOI: 10.7589/JWD-D-21-00057
Rius-Rocabert S; Arranz-Herrero J; Fernández-Valdés A; Marciello M; Moreno S; Llinares-Pinel F; Presa J; Hernandez-Alcoceba R; López-Píriz R; Torrecillas R; García A; Brun A; Filice M; Moya J.S; Cabal B; Nistal-Villan E; (2022)
Broad virus inactivation using inorganic micro/nano-particulate materials
Materials Today Bio
DOI: 10.1016/j.mtbio.2021.100191
Torre A; Bosch J; Sánchez-Vizcaíno JM; Ito S; Muñoz C; Iglesias I; Martínez-M (2022)
African swine fever survey in a European context.
Pathogens
DOI: 10.3390/pathogens11020137
Ito, S.; Bosch, J.; Martínez Avilés, M.; Sánchez-Vizcaíno, J.M (2022)
The evolution of African swine fever in China: a global threat?
Front. Vet Sci
DOI: 10.3389/fvets.2022.828498
Muñoz-Perez, C.; Bosch, J.; Ito, S.; Martínez Avilés, M.; Sánchez-Vizcaíno, J.M (2022)
Quantitative Risk Assessment of African Swine Fever Introduction into Spain by Legal Import of Live Pigs
Pathogens | 11
DOI: 10.3390/pathogens11010076
Rodríguez, A., Iglesias, I., & de la Torre, A (2022)
Prioritisation tool for targeting the monitoring of veterinary pharmaceuticals in soils at a national level: the case of Spain.
European Journal of Soil Science
DOI: 10.1111/ejss.13268
Platero L.; Garcia-Sanchez, P.; Sainz, T., Calvo C., Iglesias I., Esperon F., de la Fuente R., Frauca E., Perez-Martinez A., Mendez-Echevarria A. (2022)
Pets for pediatric transplant recipients: To have or not to have
Frontiers in Veterinary Science
DOI: 10.3389/fvets.2022.974665
Duarte-Benvenuto, A.; Sacristán, C.; Ewbank, A.C.; Sacristán, I.; Zamana-Ramblas, R.; Gravena, W.; Mello, D.M.D.; Ferreira da Silva, V.M.; Marmontel, M.; Carvalho, V.L.; Marigo, J.; Catão-Dias, J.L. (2022)
Hemotropic Mycoplasma spp. in Aquatic Mammals, Amazon Basin, Brazil
Emerg Infect Dis. | 28 : 2556-2559
DOI: 10.3201/eid2812.220971
Ewbank, A.C.; Fuentes-Castillo, D.; Sacristán, C.; Esposito, F.; Fuga, B.; Cardoso, B.; Godoy, S.N.; Zamana, R.R.; Gattamorta, M.A.; Catão-Dias, J.L.; Lincopan, N. (2022)
World Health Organization critical priority Escherichia coli clone ST648 in magnificent frigatebird (Fregata magnificens) of an uninhabited insular environment
Front Microbiol
DOI: 10.3389/fmicb.2022.940600
Ito, S.; Bosch, J.; Jeong, H.; Aguilar-Vega, C.; Park, J.; Martínez-Avilés, M.; Sánchez-Vizcaíno, J.M. (2022)
Spatio-Temporal Epidemiology of the Spread of African Swine Fever in Wild Boar and the Role of Environmental Factors in South Korea
Viruses | 14
DOI: 10.3390/v14122779
Ewbank, A.C., Esperón, F., Sacristán, C., Sacristán, I., Krul, R., Macedo Cavalcanti, E., Calatayud, O., Bueno, I., de Francisco Strefezzi, R., Catão-Dias, J.L. (2021)
Seabirds as anthropization indicators in two different tropical biotopes: A One Health approach to the issue of antimicrobial resistance genes pollution in oceanic islands
Science of the Total Environment | 754
DOI: 10.1016/j.scitotenv.2020.142141
Espinosa, J.C., Marín-Moreno, A., Aguilar-Calvo, P., Torres, J.M. (2021)
Met166-Glu168 residues in human PrP β2-α2 loop account for evolutionary resistance to prion infection
Neuropathology and Applied Neurobiology
DOI: 10.1111/nan.12676
José Manuel Rojas, Diego Barba-Moreno, Miguel Avia, Noemí Sevilla, Verónica Martín (2021)
Vaccination With Recombinant Adenoviruses Expressing the Bluetongue Virus Subunits VP7 and VP2 Provides Protection Against Heterologous Virus Challenge
Frontiers in Veterinary Science
DOI: 10.3389/fvets.2021.645561
Giselle Rangel, Juan Bárcena, Noelia Moreno, Carlos P Mata, José R Castón, Alí Alejo, Esther Blanco (2021)
Chimeric RHDV Virus-Like Particles Displaying Foot-and-Mouth Disease Virus Epitopes Elicit Neutralizing Antibodies and Confer Partial Protection in Pigs
Vaccines
DOI: 10.3390/vaccines9050470
Giselle Rangel, Verónica Martín, Juan Bárcena, Esther Blanco, Alí Alejo (2021)
An Adenovirus Vector Expressing FMDV RNA Polymerase Combined with a Chimeric VLP Harboring a Neutralizing Epitope as a Prime Boost Strategy to Induce FMDV-Specific Humoral and Cellular Responses
Pharmaceuticals
DOI: 10.3390/ph14070675
Daniel Rodríguez-Martín, José Manuel Rojas, Francesca Macchi, Valentina Franceschi, Luca Russo, Noemí Sevilla, Gaetano Donofrío, Verónica Martín (2021)
Immunization With Bovine Herpesvirus-4-Based Vector Delivering PPRV-H Protein Protects Sheep From PPRV Challenge
Frontiers in Immunology
DOI: 10.3389/fimmu.2021.705539
Ximelis T; Marín-Moreno A; Espinosa J.C; Eraña H; Charco J.M; Hernández I; Riveira C; Alcolea D; González-Roca E; Aldecoa I; Molina-Porcel L; Parchi P; Rossi M; Castilla J; Ruiz-García R; Gelpi E; Torres J.M; Sánchez-Valle R; (2021)
Homozygous R136S mutation in PRNP gene causes inherited early onset prion disease
Alzheimer's Research and Therapy
DOI: 10.1186/s13195-021-00912-6
Marín B; Otero A; Lugan S; Espinosa J.C; Marín-Moreno A; Vidal E; Hedman C; Romero A; Pumarola M; Badiola J.J; Torres J.M; Andréoletti O; Bolea R; (2021)
Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie
Scientific Reports
DOI: 10.1038/s41598-021-96818-2
Marín-Moreno A; Espinosa J.C; Aguilar-Calvo P; Fernández-Borges N; Pitarch J.L; González L; Torres J.M; (2021)
Canine D163-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context
Scientific Reports
DOI: 10.1038/s41598-021-93594-x
Marín-Moreno A; Aguilar-Calvo P; Espinosa J.C; Zamora-Ceballos M; Pitarch J.L; González L; Fernández-Borges N; Orge L; Andréoletti O; Nonno R; Torres J.M; (2021)
Classical scrapie in small ruminants is caused by at least four different prion strains
Veterinary Research
DOI: 10.1186/s13567-021-00929-7
Cali I; Espinosa J.C; Nemani S.K; Marin-Moreno A; Camacho M.V; Aslam R; Kitamoto T; Appleby B.S; Torres J.M; Gambetti P; (2021)
Two distinct conformers of PrPD type 1 of sporadic Creutzfeldt–Jakob disease with codon 129VV genotype faithfully propagate in vivo
Acta Neuropathologica Communications
DOI: 10.1186/s40478-021-01132-7
de la Torre A; Hartmann A; Wester A.L; Aminov R; (2021)
Editorial: Antimicrobials in Wildlife and the Environment
Frontiers in Microbiology
DOI: 10.3389/fmicb.2021.783118
Sacristán I; Esperón F; Pérez R; Acuña F; Aguilar E; García S; López M.J; Neves E; Cabello J; Hidalgo-Hermoso E; Terio K.A; Millán J; Poulin E; Napolitano C; (2021)
Epidemiology and molecular characterization of Carnivore protoparvovirus-1 infection in the wild felid Leopardus guigna in Chile
Transboundary and Emerging Diseases
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Nieto-Claudin A; Deem S.L; Rodríguez C; Cano S; Moity N; Cabrera F; Esperón F; (2021)
Antimicrobial resistance in Galapagos tortoises as an indicator of the growing human footprint
Environmental Pollution
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Diaz-Lucena D; Kruse N; Thüne K; Schmitz M; Villar-Piqué A; da Cunha J.E.G; Hermann P; López-Pérez Ó; Andrés-Benito P; Ladogana A; Calero M; Vidal E; Riggert J; Pineau H; Sim V; Zetterberg H; Blennow K; del Río J.A; Marín-Moreno A; Espinosa J.C; Torres J.M; Sánchez-Valle R; Mollenhauer B; Ferrer I; Zerr I; Llorens F; (2021)
TREM2 expression in the brain and biological fluids in prion diseases
Acta Neuropathologica
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Toro F; Alarcón J; Márquez S; Capella J; Bahamonde P; Esperón F; Moreno-Switt A; Castro-Nallar E; (2021)
Composition and structure of the skin microbiota of rorquals off the Eastern South Pacific
FEMS Microbiology Ecology
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Ewbank A.C; Esperón F; Sacristán C; Sacristán I; Neves E; Costa-Silva S; Antonelli M; Rocha Lorenço J; Kolesnikovas C.K.M; Catão-Dias J.L; (2021)
Occurrence and Quantification of Antimicrobial Resistance Genes in the Gastrointestinal Microbiome of Two Wild Seabird Species With Contrasting Behaviors
Frontiers in Veterinary Science
DOI: 10.3389/fvets.2021.651781
Espinosa J.C; MarÃ-N-Moreno A; Aguilar-Calvo P; Benestad S.L; Andreoletti O; Torres J.M; (2021)
Porcine Prion Protein as a Paradigm of Limited Susceptibility to Prion Strain Propagation
Journal of Infectious Diseases
DOI: 10.1093/infdis/jiz646
Espinosa J.C; Andreoletti O; Marín-Moreno A; Lugan S; Aguilar-Calvo P; Cassard H; Lorenzo P; Douet J.-Y; Villa-Díaz A; Aron N; Prieto I; Huor A; Torres J.M; (2021)
Allelic interference in prion replication is modulated by the convertibility of the interfering prpc and other host-specific factors
mBio
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Douet J.-Y; Huor A; Cassard H; Lugan S; Aron N; Arnold M; Vilette D; Torres J.-M; Ironside J.W; Andreoletti O; (2021)
Wide distribution of prion infectivity in the peripheral tissues of vCJD and sCJD patients
Acta Neuropathologica
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Sánchez-Vizcaíno J.M; Laddomada A; Martínez Avilés M; (2021)
Editorial: African Swine Fever
Frontiers in Veterinary Science
DOI: 10.3389/fvets.2020.632292
Hernández-Jover M; Phiri B.J; Stringer L; Martínez Avilés M; (2021)
Editorial: Developments in Animal Health Surveillance
Frontiers in Veterinary Science
DOI: 10.3389/fvets.2020.637364
Nieto-Claudín A; Palmer J.L; Esperón F; Deem S.L; (2021)
Haematology and plasma biochemistry reference intervals for the critically endangered western Santa Cruz Galapagos tortoise (Chelonoidis porteri)
Conservation Physiology
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Bistaffa E; Marín-Moreno A; Espinosa J.C; De Luca C.M.G; Cazzaniga F.A; Portaleone S.M; Celauro L; Legname G; Giaccone G; Torres J.M; Moda F; (2021)
Pmca-generated prions from the olfactory mucosa of patients with fatal familial insomnia cause prion disease in mice
eLife
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Calvo-Pinilla, E., Marín-López, A., Moreno, S., Lorenzo, G., Utrilla-Trigo, S., Jiménez-Cabello, L., Benavides, J., Nogales, A., Blasco, R., Brun, A., Ortego, J. (2020)
A protective bivalent vaccine against Rift Valley fever and bluetongue
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Two serological approaches for detection of antibodies to SARS-CoV-2 in different scenarios: a screening tool and a point-of-care test
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Mixtures of prion substrains in natural scrapie cases revealed by ovinised murine models
Scientific Reports | 10
DOI: 10.1038/s41598-020-61977-1
Nonno, R., Marin-Moreno, A., Carlos Espinosa, J., Fast, C., Van Keulen, L., Spiropoulos, J., Lantier, I., Andreoletti, O., Pirisinu, L., Di Bari, M.A., Aguilar-Calvo, P., Sklaviadis, T., Papasavva-Stylianou, P., Acutis, P.L., Acin, C., Bossers, A., Jacobs, J.G., Vaccari, G., D’Agostino, C., Chiappini, B., Lantier, F., Groschup, M.H., Agrimi, U., Maria Torres, J., Langeveld, J.P.M. (2020)
Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains
Scientific Reports | 10
DOI: 10.1038/s41598-019-57005-6
Vidaña, B., Busquets, N., Napp, S., Pérez-Ramírez, E., Jiménez-Clavero, M.Á., Johnson, N. (2020)
The role of birds of prey in west nile virus epidemiology
Vaccines | 8 : 1-32
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Pérez-Ramírez, E., Cano-Gómez, C., Llorente, F., Adzic, B., Al Ameer, M., Djadjovski, I., Hage, J.E., Mellouli, F.E., Goletic, T., Hovsepyan, H., Karayel-Hacioglu, I., Zoric, J.M., Mejri, S., Sadaoui, H., Salem, S.H., Sherifi, K., Toklikishvili, N., Vodica, A., Monaco, F., Brun, A., Jiménez-Clavero, M.Á., Fernández-Pinero, J. (2020)
External quality assessment of Rift Valley fever diagnosis in 17 veterinary laboratories of the Mediterranean and Black Sea regions
PLoS ONE | 15
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Esperón, F., Albero, B., Ugarte-Ruíz, M., Domínguez, L., Carballo, M., Tadeo, J.L., del Mar Delgado, M., Moreno, M.Á., de la Torre, A. (2020)
Assessing the benefits of composting poultry manure in reducing antimicrobial residues, pathogenic bacteria, and antimicrobial resistance genes: a field-scale study
Environmental Science and Pollution Research | 27 : 27738-27749
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Cevidanes, A., Esperón, F., Di Cataldo, S., Neves, E., Sallaberry-Pincheira, N., Millán, J. (2020)
Antimicrobial resistance genes in Andean foxes inhabiting anthropized landscapes in central Chile
Science of the Total Environment | 724
DOI: 10.1016/j.scitotenv.2020.138247
Espinosa, J.C., Marín-Moreno, A., Aguilar-Calvo, P., Benestad, S.L., Andreoletti, O., Torres, J.M. (2020)
Erratum: Porcine Prion Protein as a Paradigm of Limited Susceptibility to Prion Strain Propagation (J Infect Dis DOI: 10.1093/infdis/jiz646)
Journal of Infectious Diseases | 221
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Igel-Egalon, A., Laferrière, F., Tixador, P., Moudjou, M., Herzog, L., Reine, F., Torres, J.M., Laude, H., Rezaei, H., Béringue, V. (2020)
Crossing Species Barriers Relies on Structurally Distinct Prion Assemblies and Their Complementation
Molecular Neurobiology | 57 : 2572-2587
DOI: 10.1007/s12035-020-01897-3
Toivonen, J.M., Sanz-rubio, D., López-pérez, Ó., Marín-moreno, A., Bolea, R., Osta, R., Badiola, J.J., Zaragoza, P., Espinosa, J.-C., Torres, J.-M., Martín-burriel, I. (2020)
MicroRNA alterations in a tg501 mouse model of prion disease
Biomolecules | 10 : 1-21
DOI: 10.3390/biom10060908
Cassard, H., Huor, A., Espinosa, J.-C., Douet, J.-Y., Lugan, S., Aron, N., Vilette, D., Delisle, M.-B., Marín-Moreno, A., Peran, P., Beringue, V., Torres, J.M., Ironside, J.W., Andreoletti, O. (2020)
Prions from sporadic creutzfeldt-jakob disease patients propagate as strain mixtures
mBio | 11 : 1-19
DOI: 10.1128/MBIO.00393-20
Elizalde, M., Cano-Gómez, C., Llorente, F., Pérez-Ramírez, E., Casades-Martí, L., Aguilera-Sepúlveda, P., Ruiz-Fons, F., Jiménez-Clavero, M.Á., Fernández-Pinero, J. (2020)
A Duplex Quantitative Real-Time Reverse Transcription-PCR for Simultaneous Detection and Differentiation of Flaviviruses of the Japanese Encephalitis and Ntaya Serocomplexes in Birds
Frontiers in Veterinary Science | 7
DOI: 10.3389/fvets.2020.00203
Martínez-Avilés, M., Iglesias, I., De La Torre, A. (2020)
Evolution of the ASF Infection Stage in Wild Boar Within the EU (2014–2018)
Frontiers in Veterinary Science | 7
DOI: 10.3389/fvets.2020.00155
Calatayud, O., Esperón, F., Velarde, R., Oleaga, Á., Llaneza, L., Ribas, A., Negre, N., de la Torre, A., Rodríguez, A., Millán, J. (2020)
Genetic characterization of Carnivore Parvoviruses in Spanish wildlife reveals domestic dog and cat-related sequences
Transboundary and Emerging Diseases | 67 : 626-634
DOI: 10.1111/tbed.13378
Sacristán, I., Esperón, F., Acuña, F., Aguilar, E., García, S., López, M.J., Cevidanes, A., Neves, E., Cabello, J., Hidalgo-Hermoso, E., Poulin, E., Millán, J., Napolitano, C. (2020)
Antibiotic resistance genes as landscape anthropization indicators: Using a wild felid as sentinel in Chile
Science of the Total Environment | 703
DOI: 10.1016/j.scitotenv.2019.134900
Marín-Moreno, A., Espinosa, J.C., Torres, J.M. (2020)
Transgenic mouse models for the study of prion diseases
Progress in Molecular Biology and Translational Science | 175 : 147-177
DOI: 10.1016/bs.pmbts.2020.08.007
Bosch, J., Iglesias, I., Martínez, M., de la Torre, A. (2020)
Climatic and topographic tolerance limits of wild boar in eurasia: Implications for their expansion
Geography, Environment, Sustainability | 13 : 107-114
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Guerrero-Carvajal, F., Bravo-Barriga, D., Martín-Cuervo, M., Aguilera-Sepúlveda, P., Ferraguti, M., Jiménez-Clavero, M.Á., Llorente, F., Alonso, J.M., Frontera, E. (2020)
Serological evidence of co-circulation of West Nile and Usutu viruses in equids from western Spain
Transboundary and Emerging Diseases
DOI: 10.1111/tbed.13810
Hoste, A.C.R., Ruiz, T., Fernández-Pacheco, P., Jiménez-Clavero, M.Á., Djadjovski, I., Moreno, S., Brun, A., Edwards, T.A., Barr, J.N., Rueda, P., Sastre, P. (2020)
Development of a multiplex assay for antibody detection in serum against pathogens affecting ruminants
Transboundary and Emerging Diseases
DOI: 10.1111/tbed.13776
Nicolas de Francisco, O., Esperón, F., Juan-Sallés, C., Ewbank, A.C., das Neves, C.G., Marco, A., Neves, E., Anderson, N., Sacristán, C. (2020)
Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola)
Transboundary and Emerging Diseases
DOI: 10.1111/tbed.13713
Bélondrade, M., Jas-Duval, C., Nicot, S., Bruyère-Ostells, L., Mayran, C., Herzog, L., Reine, F., Torres, J.M., Fournier-Wirth, C., Béringue, V., Lehmann, S., Bougarda, D. (2020)
Correlation between bioassay and protein misfolding cyclic amplification for variant creutzfeldt-jakob disease decontamination studies
mSphere | 5
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The role of different Culex mosquito species in the transmission of West Nile virus and avian malaria parasites in Mediterranean areas
Transboundary and Emerging Diseases
DOI: 10.1111/tbed.13760
Dente, M.G., Riccardo, F., Van Bortel, W., Marrama, L., Mollet, T., Derrough, T., Sudre, B., Calistri, P., Nacca, G., Ranghiasci, A., Escadafal, C., Gaayeb, L., Guillot, A., Jiménez-Clavero, M.A., Manuguerra, J.-C., Mikaty, G., Picard, M., Fernández-Pinero, J., Pérez-Ramírez, E., Robert, V., Victoir, K., Declich, S. (2020)
Enhancing Preparedness for Arbovirus Infections with a One Health Approach: The Development and Implementation of Multisectoral Risk Assessment Exercises
BioMed Research International | 2020
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From troubles to solutions: Conservation of mediterranean tortoises under global change
Basic and Applied Herpetology | 34 : 5-16
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José Manuel Rojas, Alí Alejo, Jose Miguel Avia, Daniel Rodríguez-Martín, Carolina Sánchez, Antonio Alcamí, Noemí Sevilla, Verónica Martín (2020)
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Vaccines
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Hemoplasmas Are Endemic and Cause Asymptomatic Infection in the Endangered Darwin’s Fox (Lycalopex fulvipes)
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Transgenic mouse models expressing human and macaque prion protein exhibit similar prion susceptibility on a strain-dependent manner
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CONVOCATORIA 2021. PROYECTOS DE GENERACIÓN DE CONOCIMIENTO. Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia.
MULTVAC-40FP8: DISEÑO DE UNA PLATAFORMA VACUNAL MULTIVALENTE BASADA EN LA VARIANTE 40FP8 DEL VIRUS DE LA FIEBRE DEL VALLE DEL RIFT
2021 - 2023 | PID2021-122567OB-I00/ AEI/10.13039/501100011033/ FEDER, UE
CONVOCATORIA 2020. PROYECTOS DE I+D+I: -PROYECTOS DE “GENERACIÓN DE CONOCIMIENTO” (PGC) -PROYECTOS “RETOS INVESTIGACIÓN” (RTI)
GENERACIÓN DE VACUNAS UNIVERSALES DIVA FRENTE AL VIRUS DE LA LENGUA AZUL BASADAS EN VECTORES VIRALES VACCINIA ANKARA MODIFICADOS BICISTRÓNICOS Y ENSAYOS CELULARES PARA LA DETECCIÓN RÁPIDA DE ANTICUERPOS NEUTRALIZANTES.
2021 - 2023 | PID2020-112992R R-I00/ AEI/10.13039/501100011033
CONVOCATORIA 2021. PROYECTOS DE GENERACIÓN DE CONOCIMIENTO. Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia
MECONBLUEPEST: MECANISMOS DE EVASIÓN DE LA RESPUESTA INMUNE Y ESTRATEGIAS DE CONTROL DEL VIRUS DE LA LENGUA AZUL (BTV) Y DEL VIRUS DE LA PESTE DE LOS PEQUEÑOS RUMIANTES (PPRV)
2021 - 2024 | PID2021-124872OB-I00/ AEI/10.13039/501100011033/ FEDER, UE
CONVOCATORIA 2020. PROYECTOS DE I+D+I: -PROYECTOS DE “GENERACIÓN DE CONOCIMIENTO” (PGC) -PROYECTOS “RETOS INVESTIGACIÓN” (RTI)
NUEVAS CEPAS EMERGENTES DE VIRUS WEST NILE: ANÁLISIS DE LA INFECCIÓN EN HOSPEDADORES VERTEBRADOS Y SU PROPAGACIÓN GEOGRÁFICA)
2021 - 2024 | PID2020-116768RR-C21/ AEI/10.13039/501100011033
CONVOCATORIA 2021. PROYECTOS DE I+D+I PARA LA REALIZACIÓN DE PRUEBAS DE CONCEPTO
SEGURIDAD Y EFICACIA VACUNAL DE LA VARIANTE 40FP8 DEL VIRUS DE LA FIEBRE DEL VALLE DEL RIFT (SAFERIFVAC)
2021 - 2023 | PDC2021-121717-I00
CONVOCATORIA 2020. PROYECTOS DE I+D+I: -PROYECTOS DE “GENERACIÓN DE CONOCIMIENTO” (PGC) -PROYECTOS “RETOS INVESTIGACIÓN” (RTI)
Relación entre la microbiota, composición de la dieta y respuesta a vacunación en trucha arcoíris (Oncorhynchus Mykiss)
2020 - 2023 | PID2020-113268RB-I00/ AEI/10.13039/501100011033
Financiado por MCIN/ AEI/10.13039/501100011033/ y la Unión Europea “NextGenerationEU”/PRTR-
Development of New Technologies to Track Emerging Infectious Threats in Wildlife and the Environment (NEXTHREAT)
2021 - 2024 | PLEC2021- 007968
Proyectos de I+D+I en el marco de los programas estatales de generación de conocimiento y fortalecimiento científico y tecnológico del sistema de I+D+I y de I+D+I orientada a los retos de la sociedad. Convocatoria 2019.
Prevención y Control de enfermedades víricas ganaderas mediante Bionanopartículas: pseudopartículas virales modificadas y vesículas extracelulares.
2020 - 2023 | PID2019-107145RB-I00
Proyectos de I+D+I “Programación conjunta Internacional”, contempladas en el Programa Estatal de I+D+I orientada a los retos de la sociedad, en el marco del Plan Estatal de Investigación Científica y Técnica y de Innovación 2017 -2020, convocatoria 2019.
Mejora de las medidas preventivas frente a lagovirus emergentes en el área mediterránea; desarrollo y optimización de metodologías para la detección y control de patógenos
2019 - 2022 | PCI2019-103732
Resolución de la presidencia de la Agencia Estatal de Investigación, por la que se conceden ayudas correspondientes a la convocatoria 2019 a "Proyectos de I+D+I"
Evolución a través de la barrera de especie del potecial zoonotico de los priones emergentes
2020 - 2024 | PID2019-105837RB-I00
Resolución del procedimiento de concesión directa de ayudas del año 2020, a proyectos de investigación seleccionados en las convocatorias competitivas internacionales, en el marco de actuaciones de "Programación Conjunta Internacional"
Tackling Chronic Wasting Disease in Europe
2021 - 2024 | PCI2020-120680-2/AEI/10.13039/501100011033
Establishment of networks of human and animal virology laboratories and of medical entomology
2014 - 2018 | IFS/2013/330961 MEDILABSECURE
Patogénesis y diagnóstico de la peste equina africana
2017 - 2021 | AT 2017-001
Análisis de nuevos brotes de encefalitis por virus West Nile (Nilo Occidental) en España y su expansión geográfica
2017 - 2020 | E-RTA2015-00002-C02-00
Metagenomic array detection of emerging viruses in EU
2018 - 2019 | JRP04-ET-1-MAD-VIR

Pilar Aguilera Sepúlveda
Análisis de nuevos brotes de encefalitis por virus West Nile (Nilo Occidental) en España y su expansión geográfica
Dirección:
Belén Rebollo Polo
Desarrollo de nuevas herramientas para el diagnóstico y control de la infección por el virus West Nile (Nilo Occidental). (2019(
Dirección:
Javier del Amo González
El virus West Nile: estudio experimental de su interacción con un hospedador natural, el gorrión común, y desarrollo de un método cuantitativo para su detección diferencial (2017)
Dirección:
Virginia Pelayo Rincón
La peste porcina africana en el este de Europa: evolución de los aislados circulantes y evaluación de las herramientas diagnósticas para su control (2016)
Dirección:
Cristina Cano Gómez
Estudios epidemiológicos y moleculares sobre virus entéricos porcinos en España: aplicaciones al diagnóstico del virus de la enfermedad vesicular del cerdo (2013)
Dirección:
Elena Sotelo Girón
Aportaciones a la detección y caracterización fenotípica y molecular del virus West Nile (Nilo occidental): primeros aislados españoles (2010)
Dirección:

Virus vacunal para Sus Scrofa frente a la peste porcina africana (Armenia/07 y derivados del genotipo II)
Patente | PCTES/2018/000069
Apoyos, asesorías y transferencias.
|